Submission Details

RAL-THA-2d450e86
Molecule(s):
O=C(Cc1ccccc1)Nc1cncc2ccccc12

RAL-THA-2d450e86-1

O=C(Cc1ccccc1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(Cl)cc1)Nc1cncc2ccccc12

RAL-THA-2d450e86-2

O=C(Cc1ccc(Cl)cc1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccc(CC(=O)Nc2cncc3ccccc23)cc1

RAL-THA-2d450e86-3

Cc1ccc(CC(=O)Nc2cncc3ccccc23)cc1

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1ccc(CC(=O)Nc2cncc3ccccc23)cc1

RAL-THA-2d450e86-4

COc1ccc(CC(=O)Nc2cncc3ccccc23)cc1

3-aminopyridine-like Assayed Check Availability on Manifold View
N#Cc1ccc(CC(=O)Nc2cncc3ccccc23)cc1

RAL-THA-2d450e86-5

N#Cc1ccc(CC(=O)Nc2cncc3ccccc23)cc1

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(F)c(Cl)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-6

O=C(Cc1ccc(F)c(Cl)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(F)cc1)Nc1cncc2ccccc12

RAL-THA-2d450e86-7

O=C(Cc1ccc(F)cc1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccc(CC(=O)Nc2cncc3ccccc23)cc1Cl

RAL-THA-2d450e86-8

Cc1ccc(CC(=O)Nc2cncc3ccccc23)cc1Cl

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(Cl)c(F)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-9

O=C(Cc1ccc(Cl)c(F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(F)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-10

O=C(Cc1cccc(F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1cccc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-2d450e86-11

COc1cccc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
N#Cc1cccc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-2d450e86-12

N#Cc1cccc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1cccc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-2d450e86-13

Cc1cccc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cc(F)cc(Cl)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-14

O=C(Cc1cc(F)cc(Cl)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-2d450e86-15

Cc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(F)cc(F)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-16

O=C(Cc1cc(F)cc(F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
N#Cc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-2d450e86-17

N#Cc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-2d450e86-18
Duplicate of:
ALP-POS-3b848b35-1

COc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

Duplicate 3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1F)Nc1cncc2ccccc12

RAL-THA-2d450e86-19

O=C(Cc1cccc(Cl)c1F)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1c(Cl)cccc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-20
Duplicate of:
MAT-POS-afd4d4fd-1

Cc1c(Cl)cccc1CC(=O)Nc1cncc2ccccc12

Duplicate 3-aminopyridine-like Check Availability on Manifold View
N#Cc1c(Cl)cccc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-21

N#Cc1c(Cl)cccc1CC(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
COc1c(Cl)cccc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-22

COc1c(Cl)cccc1CC(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(F)c1F)Nc1cncc2ccccc12

RAL-THA-2d450e86-23

O=C(Cc1cccc(F)c1F)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cc(Cl)ccc1Cl)Nc1cncc2ccccc12

RAL-THA-2d450e86-24
Duplicate of:
PET-UNK-dd44aeb6-2

O=C(Cc1cc(Cl)ccc1Cl)Nc1cncc2ccccc12

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cc(Cl)ccc1F)Nc1cncc2ccccc12

RAL-THA-2d450e86-25
Duplicate of:
PET-UNK-dd44aeb6-1

O=C(Cc1cc(Cl)ccc1F)Nc1cncc2ccccc12

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cc(F)ccc1F)Nc1cncc2ccccc12

RAL-THA-2d450e86-26

O=C(Cc1cc(F)ccc1F)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccc(Cl)cc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-27

Cc1ccc(Cl)cc1CC(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
N#Cc1ccc(Cl)cc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-28
Duplicate of:
PET-UNK-dd44aeb6-3

N#Cc1ccc(Cl)cc1CC(=O)Nc1cncc2ccccc12

Duplicate 3-aminopyridine-like Check Availability on Manifold View
COc1ccc(Cl)cc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-29
Duplicate of:
MAT-POS-3b92565d-1

COc1ccc(Cl)cc1CC(=O)Nc1cncc2ccccc12

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cncc(Cl)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-30

O=C(Cc1cncc(Cl)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(C(F)(F)F)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-31

O=C(Cc1cccc(C(F)(F)F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(C(F)(F)F)cc1)Nc1cncc2ccccc12

RAL-THA-2d450e86-32

O=C(Cc1ccc(C(F)(F)F)cc1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(Cl)cn1)Nc1cncc2ccccc12

RAL-THA-2d450e86-33

O=C(Cc1ccc(Cl)cn1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccncc1Cl)Nc1cncc2ccccc12

RAL-THA-2d450e86-34

O=C(Cc1ccncc1Cl)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cncc(F)c1)Nc1cncc2ccccc12

RAL-THA-2d450e86-35

O=C(Cc1cncc(F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Cc1ccccc1Cl)Nc1cncc2ccccc12

RAL-THA-2d450e86-36

O=C(Cc1ccccc1Cl)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccccc1F)Nc1cncc2ccccc12

RAL-THA-2d450e86-37

O=C(Cc1ccccc1F)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccccc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-38

Cc1ccccc1CC(=O)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1ccccc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-39

COc1ccccc1CC(=O)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
N#Cc1ccccc1CC(=O)Nc1cncc2ccccc12

RAL-THA-2d450e86-40

N#Cc1ccccc1CC(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Systematic exploration of SAR around MAT-POS-23a8a11a-1 and ADA-UCB-6c2cb422-1 per Design Team discussion 16 Dec 2020

Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Thu, 17 Dec 2020 19:29:18 +0000