Submission Details

RAL-THA-1d44ff04
Molecule(s):
O=C(Cc1cc(Cl)cc(OCc2ncc[nH]2)c1)Nc1cncc2ccccc12

RAL-THA-1d44ff04-1

O=C(Cc1cc(Cl)cc(OCc2ncc[nH]2)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(OCc2ncn[nH]2)c1)Nc1cncc2ccccc12

RAL-THA-1d44ff04-2

O=C(Cc1cc(Cl)cc(OCc2ncn[nH]2)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-3

CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
NC(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-4

NC(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-5

CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-6

COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(-c2ncc[nH]2)c1)Nc1cncc2ccccc12

RAL-THA-1d44ff04-7

O=C(Cc1cc(Cl)cc(-c2ncc[nH]2)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(-c2nnc[nH]2)c1)Nc1cncc2ccccc12

RAL-THA-1d44ff04-8

O=C(Cc1cc(Cl)cc(-c2nnc[nH]2)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
CS(=O)(=O)NCc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-9

CS(=O)(=O)NCc1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
NS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-10

NS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

RAL-THA-1d44ff04-11

CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(Oc2ccc[nH]c2=O)c1)Nc1cncc2ccccc12

RAL-THA-1d44ff04-12

O=C(Cc1cc(Cl)cc(Oc2ccc[nH]c2=O)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(C(=O)NO)c1)Nc1cncc2ccccc12

RAL-THA-1d44ff04-13

O=C(Cc1cc(Cl)cc(C(=O)NO)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Follow up of ALP-POS-3b848b35-2. Beta-lactam replacements: Small substituents providing a HBD. See also RAL-THA-6b94ceba.

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Tue, 29 Sep 2020 20:54:56 +0000