Submission Details

PET-UNK-7be94445
Molecule(s):
O=C1N(c2cccc(Cl)c2)CCCN1c1cncc2ccccc12

PET-UNK-7be94445-1

O=C1N(c2cccc(Cl)c2)CCCN1c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C1N(c2cccc(Cl)c2)CCN1c1cncc2ccccc12

PET-UNK-7be94445-2

O=C1N(c2cccc(Cl)c2)CCN1c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Cyclic analogs of ADA-UCB-6c2cb422-1

Other Notes:

The two submitted structures are cyclic urea analogs of the lactams PET-UNK-c9c1e0d8-3 and PET-UNK-c9c1e0d8-4. I anticipate that these two cyclic ureas will be less potent than the corresponding lactams (poorer geometry) although the carbonyl oxygens are likely to be better hydrogen bond acceptors.

Inspired By:
Discussion:

Contributor: Peter Kenny - Tue, 28 Jul 2020 14:59:46 +0000