Submission Details

NAU-LAT-b7d8c353
Molecule(s):
NCc1cncc(NC(=O)C2CCOc3ccc(Cl)cc32)c1

NAU-LAT-b7d8c353-1

NCc1cncc(NC(=O)C2CCOc3ccc(Cl)cc32)c1

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2c1CCNC2)C1CCOc2ccc(Cl)cc21

NAU-LAT-b7d8c353-2

O=C(Nc1cncc2c1CCNC2)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cc(=O)[nH]c2ccccc12)C1CCOc2ccc(Cl)cc21

NAU-LAT-b7d8c353-3
Duplicate of:
JAG-UCB-c61058a9-45

O=C(Nc1cc(=O)[nH]c2ccccc12)C1CCOc2ccc(Cl)cc21

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cc[nH]c(=O)c1)C1CCOc2ccc(Cl)cc21

NAU-LAT-b7d8c353-4
Duplicate of:
BEN-DND-b89db3f2-2

O=C(Nc1cc[nH]c(=O)c1)C1CCOc2ccc(Cl)cc21

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cnccc1-n1cccn1)C1CCOc2ccc(Cl)cc21

NAU-LAT-b7d8c353-5

O=C(Nc1cnccc1-n1cccn1)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CN1CCN(c2ccncc2NC(=O)C2CCOc3ccc(Cl)cc32)CC1

NAU-LAT-b7d8c353-6

CN1CCN(c2ccncc2NC(=O)C2CCOc3ccc(Cl)cc32)CC1

3-aminopyridine-like Check Availability on Manifold View
Cn1ccc(NC(=O)C2CCOc3ccc(Cl)cc32)cc1=O

NAU-LAT-b7d8c353-7

Cn1ccc(NC(=O)C2CCOc3ccc(Cl)cc32)cc1=O

3-aminopyridine-like Check Availability on Manifold View
NCc1cccc2c(NC(=O)C3CCOc4ccc(Cl)cc43)cncc12

NAU-LAT-b7d8c353-8

NCc1cccc2c(NC(=O)C3CCOc4ccc(Cl)cc43)cncc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Expansion, bioisosteric replacements of VLA-UCB-1dbca3b4-15. Attempting to add an interaction with Glu166.

Inspired By:
Discussion:

Contributor: Nauris Narvaiss, Latvian Institute of Organic Synthesis - Wed, 30 Sep 2020 20:20:01 +0000