Submission Details

NAU-LAT-4ce8bf23
Molecule(s):
CC(=O)NCC(C(=O)Nc1cccc(Cl)c1)c1cncc2ccccc12

NAU-LAT-4ce8bf23-1

CC(=O)NCC(C(=O)Nc1cccc(Cl)c1)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
NC(=O)CCN(C(=O)Cc1cccc(Cl)c1)c1cncc2ccccc12

NAU-LAT-4ce8bf23-2

NC(=O)CCN(C(=O)Cc1cccc(Cl)c1)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
CC(=O)NC(C(=O)Nc1cccc(Cl)c1)c1cncc2ccccc12

NAU-LAT-4ce8bf23-3

CC(=O)NC(C(=O)Nc1cccc(Cl)c1)c1cncc2ccccc12

Design Rationale:

Many chloro-acetamide hits have the interaction of acetamide carbonyl with Gly143. Attempting to add this interaction to isoquinoline hit.

Inspired By:
Discussion:

Contributor: Nauris Narvaiss, Latvian Institute of Organic Synthesis - Thu, 12 Nov 2020 22:31:35 +0000