Submission Details

MIC-UNK-66895286
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1cn[nH]c1

MIC-UNK-66895286-1

O=C(Cc1cccc(Cl)c1)Nc1cn[nH]c1

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cn[nH]c1)Nc1cccc(Cl)c1

MIC-UNK-66895286-2

O=C(Cc1cn[nH]c1)Nc1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1[nH]ncc1CC(=O)Nc1cccc(Cl)c1

MIC-UNK-66895286-3

Cc1[nH]ncc1CC(=O)Nc1cccc(Cl)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1cc(O)ncc1CC(=O)Nc1cccc(Cl)c1

MIC-UNK-66895286-4

Cc1cc(O)ncc1CC(=O)Nc1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cnc(O)c2ccccc12)Nc1cccc(Cl)c1

MIC-UNK-66895286-5

O=C(Cc1cnc(O)c2ccccc12)Nc1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Attempt to bind Phe140 and/or Glu166 (like in x2910) by modifying pyridine from several successful aminopyridine compounds

Other Notes:

Other analogues are possible, but some look like iminoquinones and can be redox-active

Inspired By:
Discussion:

Contributor: Michal K - Sat, 06 Jun 2020 14:58:43 +0000