Submission Details

MIC-UNK-50cce87d
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1cncc2cccc(F)c12

MIC-UNK-50cce87d-1

O=C(Cc1cccc(Cl)c1)Nc1cncc2cccc(F)c12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1cncc2cccc(Cl)c12

MIC-UNK-50cce87d-2

O=C(Cc1cccc(Cl)c1)Nc1cncc2cccc(Cl)c12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1cccc2cncc(NC(=O)Cc3cccc(Cl)c3)c12

MIC-UNK-50cce87d-3

Cc1cccc2cncc(NC(=O)Cc3cccc(Cl)c3)c12

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1cccc2cncc(NC(=O)Cc3cccc(Cl)c3)c12

MIC-UNK-50cce87d-4

COc1cccc2cncc(NC(=O)Cc3cccc(Cl)c3)c12

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C1C(c2cccc(Cl)c2)CCN1c1cncc2cccc(F)c12

MIC-UNK-50cce87d-5

O=C1C(c2cccc(Cl)c2)CCN1c1cncc2cccc(F)c12

3-aminopyridine-like Check Availability on Manifold View
O=C1C(c2cccc(Cl)c2)CCN1c1cncc2cccc(Cl)c12

MIC-UNK-50cce87d-6

O=C1C(c2cccc(Cl)c2)CCN1c1cncc2cccc(Cl)c12

3-aminopyridine-like Check Availability on Manifold View
Cc1cccc2cncc(N3CCC(c4cccc(Cl)c4)C3=O)c12

MIC-UNK-50cce87d-7

Cc1cccc2cncc(N3CCC(c4cccc(Cl)c4)C3=O)c12

3-aminopyridine-like Check Availability on Manifold View
COc1cccc2cncc(N3CCC(c4cccc(Cl)c4)C3=O)c12

MIC-UNK-50cce87d-8

COc1cccc2cncc(N3CCC(c4cccc(Cl)c4)C3=O)c12

3-aminopyridine-like Check Availability on Manifold View
O=C1C(c2cccc(Cl)c2)CCCN1c1cncc2cccc(F)c12

MIC-UNK-50cce87d-9

O=C1C(c2cccc(Cl)c2)CCCN1c1cncc2cccc(F)c12

3-aminopyridine-like Check Availability on Manifold View
O=C1C(c2cccc(Cl)c2)CCCN1c1cncc2cccc(Cl)c12

MIC-UNK-50cce87d-10

O=C1C(c2cccc(Cl)c2)CCCN1c1cncc2cccc(Cl)c12

3-aminopyridine-like Check Availability on Manifold View
Cc1cccc2cncc(N3CCCC(c4cccc(Cl)c4)C3=O)c12

MIC-UNK-50cce87d-11

Cc1cccc2cncc(N3CCCC(c4cccc(Cl)c4)C3=O)c12

3-aminopyridine-like Check Availability on Manifold View
COc1cccc2cncc(N3CCCC(c4cccc(Cl)c4)C3=O)c12

MIC-UNK-50cce87d-12

COc1cccc2cncc(N3CCCC(c4cccc(Cl)c4)C3=O)c12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Similiar reasoning to one in EDJ-MED-6af13d92 - bending amide out of plane with peri- substituent. It would work much better with N-substituent that does not catastrophically compromise activity, but synthesis of such compound will be much harder.

Inspired By:
Discussion:

Contributor: Michal K - Sat, 24 Oct 2020 07:59:41 +0000