Submission Details

Molecule(s):
O=C(Cc1cc(Cl)cc(OC(F)F)c1)Nc1cncc2ccccc12

MIC-UNK-16ccb665-1

O=C(Cc1cc(Cl)cc(OC(F)F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(SC(F)F)c1)Nc1cncc2ccccc12

MIC-UNK-16ccb665-2

O=C(Cc1cc(Cl)cc(SC(F)F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cc(Cl)cc(C(F)F)c1)Nc1cncc2ccccc12

MIC-UNK-16ccb665-3

O=C(Cc1cc(Cl)cc(C(F)F)c1)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

CF2H group can provide hydrogen bond donor into beta-lactam pocket

Inspired By:
Discussion: