Submission Details

MIC-UNK-0a05c952
Molecule(s):
O=C1C(c2cccc(Cl)c2)CC(C2CO2)N1c1cncc2ccccc12

MIC-UNK-0a05c952-1

O=C1C(c2cccc(Cl)c2)CC(C2CO2)N1c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C1C(c2cccc(Cl)c2)CCC(C2CO2)N1c1cncc2ccccc12

MIC-UNK-0a05c952-2

O=C1C(c2cccc(Cl)c2)CCC(C2CO2)N1c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C1C(c2ccc(Cl)c(Cl)c2)CC(C2CO2)N1c1cncc2ccccc12

MIC-UNK-0a05c952-3

O=C1C(c2ccc(Cl)c(Cl)c2)CC(C2CO2)N1c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C1C(c2ccc(Cl)c(Cl)c2)CCC(C2CO2)N1c1cncc2ccccc12

MIC-UNK-0a05c952-4

O=C1C(c2ccc(Cl)c(Cl)c2)CCC(C2CO2)N1c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Covalentized PET-UNK-c9c1e0d8-3 and -4 that avoid problems with MAT-POS-090737b9-1 instability. I'd expect that cis-isomer would be more potent

Other Notes:

While these compounds do look somewheat wacky, three last steps of synthesis could look like this: n. epioxidation, n-1. ring-closing amide formation, n-2. Petasis reaction using vinylboronic acid, aminoisoquinoline and appropriate aldehyde-ester

Inspired By:
Discussion:

Contributor: Michal K - Sun, 28 Feb 2021 04:34:24 +0000