Submission Details

Molecule(s):
N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3C3(CCN(c4cncc5cccc(Cl)c45)C3=O)C2)CC1

MAT-POS-1d5ab790-1
Duplicate of:
MAT-POS-853c0ffa-5

N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3C3(CCN(c4cncc5cccc(Cl)c45)C3=O)C2)CC1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
CNC(=O)CN1Cc2ccc(Cl)cc2C2(CCN(c3cncc4cccc(Cl)c34)C2=O)C1

MAT-POS-1d5ab790-2
Duplicate of:
MAT-POS-b4d6b7fc-6

CNC(=O)CN1Cc2ccc(Cl)cc2C2(CCN(c3cncc4cccc(Cl)c34)C2=O)C1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
CNC(=O)CN1CC2(CCN(c3cncc4cccc(Cl)c34)C2=O)c2cc(Cl)ccc2C1=O

MAT-POS-1d5ab790-3
Duplicate of:
MAT-POS-853c0ffa-1

CNC(=O)CN1CC2(CCN(c3cncc4cccc(Cl)c34)C2=O)c2cc(Cl)ccc2C1=O

Duplicate Ugi Assayed Check Availability on Manifold View

Design Rationale:

Additional isoquinoline options with spirocyclic scaffolds

Discussion: