Submission: MAT-POS-06036648

MAT-POS-06036648

Molecule(s):

MAT-POS-06036648-1

CN(C)c1ccc(N(C(=O)Cn2nnc3ccccc32)c2cccc(Cl)c2)cc1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-2

COc1cc(Cl)cc(N(C(=O)Cn2nnc3ccccc32)c2ccc(N(C)C)cc2)c1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-3

CCC(=O)Nc1ccc(N(C(=O)Cn2nnc3ccccc32)c2cccc(Cl)c2)cc1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-4

CCC(=O)Nc1ccc(N(C(=O)Cn2nnc3ccccc32)c2cc(Cl)cc(OC)c2)cc1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-5

CNc1ccc(N(C(=O)Cn2nnc3ccccc32)c2cccc(Cl)c2)cc1

3-aminopyridine-like Assayed Check Availability on Manifold View

MAT-POS-06036648-6

CNc1ccc(N(C(=O)Cn2nnc3ccccc32)c2cc(Cl)cc(OC)c2)cc1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-7

CNc1ccc(N(C(=O)Nn2cnc3ccccc3c2=O)c2cccc(Cl)c2)cc1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-8

CNc1ccc(N(C(=O)Nn2cnc3ccccc32)c2cccc(Cl)c2)cc1

3-aminopyridine-like Check Availability on Manifold View

MAT-POS-06036648-9

COc1cc(Cl)cc(NC(=O)Cn2nnc3ccccc32)c1

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

Replacing thiophene on the benzotriazole hits compounds in while exploring the chlorobenzene that makes TRY-UNI-714a760b-6 potent, as well as adding the methoxy as in AGN-NEW-891393a6-1. Could also add a beta lactam. Also exploring replacing benzotriazole with substructures from potent hits JAN-GHE-5a013bed-3 and JAN-GHE-5a013bed-2