Submission Details

MAR-UCB-fd2e172f
Molecule(s):
CO[C@@]1(C(=O)Nc2cnc(C)c3c2COC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-1

CO[C@@]1(C(=O)Nc2cnc(C)c3c2COC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3nccnc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-2

CO[C@@]1(C(=O)Nc2cncc3nccnc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnc(N)c3ncsc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-3

CO[C@@]1(C(=O)Nc2cnc(N)c3ncsc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnc(C)c3c2CCNC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-4

CO[C@@]1(C(=O)Nc2cnc(C)c3c2CCNC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnc(C)c3c2CCOC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-5

CO[C@@]1(C(=O)Nc2cnc(C)c3c2CCOC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnnc3cccnc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-6

CO[C@@]1(C(=O)Nc2cnnc3cccnc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnc(C)c3c2CCN(C)C3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-7

CO[C@@]1(C(=O)Nc2cnc(C)c3c2CCN(C)C3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3cccn23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-8

CO[C@@]1(C(=O)Nc2cncc3cccn23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2[nH]nc3ccsc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-9

CO[C@@]1(C(=O)Nc2[nH]nc3ccsc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3cc(N)ccc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-10

CO[C@@]1(C(=O)Nc2cnn3cc(N)ccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)NC2=CS(=O)(=O)c3cc(C)ccc32)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-11

CO[C@@]1(C(=O)NC2=CS(=O)(=O)c3cc(C)ccc32)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2CS(=O)(=O)CC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-12

CO[C@@]1(C(=O)Nc2cncc3c2CS(=O)(=O)CC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3oc(CN)cc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-13

CO[C@@]1(C(=O)Nc2cncc3oc(CN)cc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2CC[C@H]3N)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-14

CO[C@@]1(C(=O)Nc2cncc3c2CC[C@H]3N)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3cccc(CN)c23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-15

CO[C@@]1(C(=O)Nc2cnn3cccc(CN)c23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3cccc(Cl)c23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-16

CO[C@@]1(C(=O)Nc2cnn3cccc(Cl)c23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnc3ccc(F)cn23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-17

CO[C@@]1(C(=O)Nc2cnc3ccc(F)cn23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CN[C@@H]1CCc2c(NC(=O)[C@]3(OC)CCOc4ccc(Cl)cc43)cncc21

MAR-UCB-fd2e172f-18

CN[C@@H]1CCc2c(NC(=O)[C@]3(OC)CCOc4ccc(Cl)cc43)cncc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn(C)c2C(F)F)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-19

CO[C@@]1(C(=O)Nc2cnn(C)c2C(F)F)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3cncnc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-20

CO[C@@]1(C(=O)Nc2cncc3cncnc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc(C3CC3)c2Cl)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-21

CO[C@@]1(C(=O)Nc2cncc(C3CC3)c2Cl)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2COC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-22

CO[C@@]1(C(=O)Nc2cncc3c2COC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3ccsc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-23

CO[C@@]1(C(=O)Nc2cnn3ccsc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3sccc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-24

CO[C@@]1(C(=O)Nc2cncc3sccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3ccoc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-25

CO[C@@]1(C(=O)Nc2cncc3ccoc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2CCS(=O)(=O)C3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-26

CO[C@@]1(C(=O)Nc2cncc3c2CCS(=O)(=O)C3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2CC[C@@H]3O)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-27

CO[C@@]1(C(=O)Nc2cncc3c2CC[C@@H]3O)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3sc(CN)cc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-28

CO[C@@]1(C(=O)Nc2cncc3sc(CN)cc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2CCN3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-29

CO[C@@]1(C(=O)Nc2cncc3c2CCN3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2CN(C)CC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-30

CO[C@@]1(C(=O)Nc2cncc3c2CN(C)CC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3[nH]ccc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-31

CO[C@@]1(C(=O)Nc2cncc3[nH]ccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3cc(C)ccc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-32

CO[C@@]1(C(=O)Nc2cnn3cc(C)ccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2[nH]nc3c2CCCCC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-33

CO[C@@]1(C(=O)Nc2[nH]nc3c2CCCCC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncn3cccc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-34

CO[C@@]1(C(=O)Nc2cncn3cccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3c2C[C@@H](N)C3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-35

CO[C@@]1(C(=O)Nc2cncc3c2C[C@@H](N)C3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncn3nccc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-36

CO[C@@]1(C(=O)Nc2cncn3nccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2[nH]nc3c2CCCC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-37

CO[C@@]1(C(=O)Nc2[nH]nc3c2CCCC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3c2CSCC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-38

CO[C@@]1(C(=O)Nc2cnn3c2CSCC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2[nH]nc3c2[C@H](C)CC3)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-39

CO[C@@]1(C(=O)Nc2[nH]nc3c2[C@H](C)CC3)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cnn3cccc(F)c23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-40

CO[C@@]1(C(=O)Nc2cnn3cccc(F)c23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3occc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-41

CO[C@@]1(C(=O)Nc2cncc3occc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)NC2=CS(=O)(=O)c3cc(N)ccc32)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-42

CO[C@@]1(C(=O)NC2=CS(=O)(=O)c3cc(N)ccc32)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3sc(C(N)=O)cc23)CCOc2ccc(Cl)cc21

MAR-UCB-fd2e172f-43

CO[C@@]1(C(=O)Nc2cncc3sc(C(N)=O)cc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Bioisosteric replacements for the isoquinoline

Inspired By:
Discussion:

Contributor: Mark Calmiano, UCB - Tue, 18 May 2021 08:19:34 +0000