Submission Details

MAR-UCB-d1255a91
Molecule(s):
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)c2cnoc21

MAR-UCB-d1255a91-1

O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)c2cnoc21

O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)c2cn[nH]c21

MAR-UCB-d1255a91-2

O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)c2cn[nH]c21

Design Rationale:

Pick up Glu166 interaction via linker to replicate interaction seen in the amino pyridine series

Inspired By:
Discussion:

Contributor: Mark Calmiano, UCB - Tue, 27 Oct 2020 15:46:10 +0000