Submission Details

MAR-UCB-6ab2ec87
Molecule(s):
O=C(Nc1cncc2ccccc12)[C@@H]1CNc2ccc(Cl)cc21

MAR-UCB-6ab2ec87-1

O=C(Nc1cncc2ccccc12)[C@@H]1CNc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
C[C@H]1Nc2ccc(Cl)cc2[C@@H]1C(=O)Nc1cncc2ccccc12

MAR-UCB-6ab2ec87-2

C[C@H]1Nc2ccc(Cl)cc2[C@@H]1C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
CO[C@@]1(C(=O)Nc2cncc3ccccc23)COc2ccc(Cl)cc21

MAR-UCB-6ab2ec87-3

CO[C@@]1(C(=O)Nc2cncc3ccccc23)COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)[C@@H]1COc2c(O)cc(Cl)cc21

MAR-UCB-6ab2ec87-4

O=C(Nc1cncc2ccccc12)[C@@H]1COc2c(O)cc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccc(F)cc12)[C@@H]1COc2ccc(Cl)cc21

MAR-UCB-6ab2ec87-5

O=C(Nc1cncc2ccc(F)cc12)[C@@H]1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CN1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc21

MAR-UCB-6ab2ec87-6

CN1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc21

3-aminopyridine-like Check Availability on Manifold View
CC(=O)N1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc21

MAR-UCB-6ab2ec87-7

CC(=O)N1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Transfer positive SAR from benzopyran scaffold into the benzofuran/indoline scaffold

Inspired By:
Discussion:

Contributor: Mark Calmiano, UCB - Tue, 26 Jan 2021 12:01:30 +0000