Submission Details

Design Rationale:

Indole to benzimidazole etc replacement. Bioisosteres of ester (may establish non covalency).

Other Notes:

CHF2 is a useful aldehyde oxidase "litmus test"... usually you can simply stire the pyr with a small amount of Baran's reagent and look for a +50 in LC-MS. If this is quite significant, it's likely to be an AO substrate. However, the CHF2 might be then an AO blocker so worth testing. might also get rid of usual p450 issues with pyridines.