Submission Details

Molecule(s):
O=C(Nc1nncn1C1CC1F)C1CCOc2ccc(Cl)c(F)c21

JOH-UNI-d0d90dc1-1

O=C(Nc1nncn1C1CC1F)C1CCOc2ccc(Cl)c(F)c21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1F)[C@]1(F)CCOc2ccc(Cl)cc21

JOH-UNI-d0d90dc1-2

O=C(Nc1nncn1C1CC1F)[C@]1(F)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1F)C1CCOc2ccc(Cl)cc21

JOH-UNI-d0d90dc1-3

O=C(Nc1nncn1C1CC1F)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Cc1nnc(NC(=O)C2CCOc3ccc(Cl)c(F)c32)n1C1CC1F

JOH-UNI-d0d90dc1-4

Cc1nnc(NC(=O)C2CCOc3ccc(Cl)c(F)c32)n1C1CC1F

3-aminopyridine-like Check Availability on Manifold View
Cc1nnc(NC(=O)[C@]2(F)CCOc3ccc(Cl)cc32)n1C1CC1F

JOH-UNI-d0d90dc1-5

Cc1nnc(NC(=O)[C@]2(F)CCOc3ccc(Cl)cc32)n1C1CC1F

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

Potential ways to block metabolism, improve permeation of lead molecules at this or at a later stage.

Discussion: