Submission Details
Molecule(s):
OC(Cc1cncc(Cl)c1)c1cccc2[nH]ccc12
[O-][S+](Cc1cncc(Cl)c1)c1cccc2[nH]ccc12
OB(Cc1cncc(Cl)c1)c1cccc2[nH]ccc12
[O-][S+](Nc1cncc(Cl)c1)c1cccc2[nH]ccc12
O=C(c1cccc2[nH]ccc12)C(c1cncc(Cl)c1)C(F)(F)F
Design Rationale:
Very loosely....... T.S. inhibitor principle.If the ester is hydrolysed in MPro is there a chance of "trapping" a transition state like intermediate? Will need some effective P1, P2 etc groups and correct stereochemistry but might be an option?