Submission Details

JOH-UNI-766085ab
Molecule(s):
O=C(Nc1nncn1C1CC1)[C@]1(F)CCOc2ccc(Cl)cc21

JOH-UNI-766085ab-1

O=C(Nc1nncn1C1CC1)[C@]1(F)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

F is known to stabilise an adjacent chiral centre (from racemisation) Can also form a weak electrostatic interaction and mask a hydrogen bond (potentially lowers efflux).

Discussion:

Contributor: John SPENCER, University of Sussex - Fri, 26 Jun 2020 19:45:27 +0000