Submission Details

JOH-UNI-6fede743
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1cnc(C(F)F)c2ccccc12

JOH-UNI-6fede743-1

O=C(Cc1cccc(Cl)c1)Nc1cnc(C(F)F)c2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1c(C(F)F)ncc2ccccc12

JOH-UNI-6fede743-2

O=C(Cc1cccc(Cl)c1)Nc1c(C(F)F)ncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1c[nH]c(=O)c2ccccc12

JOH-UNI-6fede743-3
Duplicate of:
MAT-POS-bb423b95-6

O=C(Cc1cccc(Cl)c1)Nc1c[nH]c(=O)c2ccccc12

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1c(O)ncc2ccccc12

JOH-UNI-6fede743-4

O=C(Cc1cccc(Cl)c1)Nc1c(O)ncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1c(C(F)F)ncc2ccc(F)cc12

JOH-UNI-6fede743-5

O=C(Cc1cccc(Cl)c1)Nc1c(C(F)F)ncc2ccc(F)cc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

As suggested by PWK, look at AO metabolism on an easier substrate rather than having to resolve enantiomers.

Other Notes:

Happy to try these out in our lab and report results back (LC MS)

Discussion:

Contributor: John Spencer, Uni of Sussex - Sat, 31 Oct 2020 22:43:38 +0000