Submission Details
Molecule(s):
O=C(Oc1nccs1)c1cccc2[nH]ccc12
O=C(Oc1cnc(Cl)s1)c1cccc2[nH]ccc12
Cc1ncsc1OC(=O)c1cccc2[nH]ccc12
Cc1nc(C)c(OC(=O)c2cccc3[nH]ccc23)s1
O=C(Oc1scnc1Cl)c1cccc2[nH]ccc12
Design Rationale:
Can the pyridine be replaced? Thiazole might enable molecule to be conformationally restricted by sigma hole effect of sulphur? A few methyls added as "soft" metabolism spots for thiazoles and chlorine bioisosteres.