Submission Details

Molecule(s):
O=C(c1cccc2[nH]ccc12)C(F)(F)c1cncc(Cl)c1

JOH-UNI-0304dea8-1

O=C(c1cccc2[nH]ccc12)C(F)(F)c1cncc(Cl)c1

O=C(c1cccc2[nH]ccc12)C(F)c1cncc(Cl)c1

JOH-UNI-0304dea8-2

O=C(c1cccc2[nH]ccc12)C(F)c1cncc(Cl)c1

O=P(O)(Cc1cncc(Cl)c1)c1cccc2[nH]ccc12

JOH-UNI-0304dea8-3

O=P(O)(Cc1cncc(Cl)c1)c1cccc2[nH]ccc12

O[Si](O)(Cc1cncc(Cl)c1)c1cccc2[nH]ccc12

JOH-UNI-0304dea8-4

O[Si](O)(Cc1cncc(Cl)c1)c1cccc2[nH]ccc12


Design Rationale:

F's closer to C=O may favour C(OH)2 dihydrate formation over C=O.

Discussion: