Submission Details

Design Rationale:

The chloroacetamide warhead was left unchanged as my previous research on this similar molecule has only resulted in a decrease in potency when modifying the warhead. The piperazine core structure, chloroacetamide warhead and aromatic ring on the other side of the warhead appear to be part of the pharmacophore of this specific group of compounds. Lastly, some of the more potent compounds appear to have a chlorine attached to the aromatic ring indicating that could result in an increase in potency, rather than the use of the fluorine.