Submission Details

Design Rationale:

GC 376 is a Mpro inhibitor - as the bisulfite adduct of the aldedhyde (but the aldehyde is the inhibitor). The above 5-phenyl-2-pentenal and the sodium bisulfite adduct could also be a Mpro inhibitors. The propenal could inhibit as the aldehyde adduct (1,2 addition) or as the Michael adduct (1.4 addition). The bisulfite would have good solubility and would avoid metabolism to the corresponding acid would would be less active. The 5-phenylpropenal is a literature compound but the sodium bisulfite adduct is not.

Other Notes:

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