Submission Details

FRA-DIA-a1f3a927
Molecule(s):
C=C(C(=O)[C@@H]1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

FRA-DIA-a1f3a927-1

C=C(C(=O)[C@@H]1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Naive suggestion for covalentising the current best 3-aminopyridine, MAT-POS-b3e365b9-1, by dangling a ketone next to Cys145, where there appears to be space. https://fragalysis.diamond.ac.uk/viewer/react/projects/302/242

Inspired By:
Discussion:

Contributor: Frank von Delft, Diamond Light Source - Tue, 03 Nov 2020 04:35:32 +0000