Submission Details
Molecule(s):
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)C(=O)C1
O=C(c1cncc2ccccc12)N1CCN(c2cccc(Cl)c2)C(=O)C1
O=C(c1cc(=O)[nH]c2ccccc12)N1CC(=O)N(c2cccc(Cl)c2)C(CC2CCCCC2)C1
O=C(c1cc(=O)[nH]c2ccccc12)N1CC(=O)N(c2cccc(Cl)c2)C(CN2CCCCC2)C1
O=C(c1cncc2ccccc12)N1CC(=O)N(c2cccc(Cl)c2)C(CC2CCCCC2)C1
O=C(c1cncc2ccccc12)N1CC(=O)N(c2cccc(Cl)c2)C(CN2CCCCC2)C1
CC1CN(C(=O)c2cncc3ccccc23)CC(=O)N1c1cccc(Cl)c1
CC1CN(C(=O)c2cc(=O)[nH]c3ccccc23)CC(=O)N1c1cccc(Cl)c1
Design Rationale:
Pick up Glu166 interaction via linker to replicate interaction seen in the amino pyridine scaffold