Submission Details

EDJ-MED-ee742daa
Molecule(s):
COC1(C(=O)Nc2cnccc2C(F)(F)F)CCOc2ccc(Cl)cc21

EDJ-MED-ee742daa-1

COC1(C(=O)Nc2cnccc2C(F)(F)F)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnccc1C(F)(F)F)C1CCNc2cc(Cl)c(Cl)cc21

EDJ-MED-ee742daa-2

O=C(Nc1cnccc1C(F)(F)F)C1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cnccc2C(F)(F)F)CCOc2c(F)cc(F)cc21

EDJ-MED-ee742daa-3

COC1(C(=O)Nc2cnccc2C(F)(F)F)CCOc2c(F)cc(F)cc21

3-aminopyridine-like Check Availability on Manifold View
CN(C)S(=O)(=O)N1Cc2ccc(Cl)cc2C(C(=O)Nc2cnccc2C(F)(F)F)C1

EDJ-MED-ee742daa-4

CN(C)S(=O)(=O)N1Cc2ccc(Cl)cc2C(C(=O)Nc2cnccc2C(F)(F)F)C1

3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

SAM-UNK-2684b532-12 shows surprising potency in rapidfire enzyme assay - testing this as a useful isoquinoline replacement with several highly potent S2 options.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Fri, 07 May 2021 15:27:44 +0000