Submission Details

EDJ-MED-d9f3798e
Molecule(s):
CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c2c1

EDJ-MED-d9f3798e-1

CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Assayed Check Availability on Manifold View
CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CNS(=O)(=O)c4ccc(Cl)cc43)c2c1

EDJ-MED-d9f3798e-2

CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CNS(=O)(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)c2c1

EDJ-MED-d9f3798e-3

CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

EDG-MED-10fcb19e-1 has an IC50 of 145nM and the prospect of being more metabolically stable according to MedChemica MMPA analysis. Therefore make combination with more stable P2 groups.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Tue, 22 Jun 2021 11:28:34 +0000