Submission Details

EDJ-MED-d1555997
Molecule(s):
CS(=O)(=O)N1Cc2ccc(Cl)cc2C(C(=O)Nc2cncc3cccc(F)c23)C1

EDJ-MED-d1555997-1

CS(=O)(=O)N1Cc2ccc(Cl)cc2C(C(=O)Nc2cncc3cccc(F)c23)C1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1cccc2cncc(NC(=O)C3CN(S(C)(=O)=O)Cc4ccc(Cl)cc43)c12

EDJ-MED-d1555997-2

Cc1cccc2cncc(NC(=O)C3CN(S(C)(=O)=O)Cc4ccc(Cl)cc43)c12

3-aminopyridine-like Ordered Check Availability on Manifold View
Design Rationale:

Suggestion from Bobby Glen to introduce 8 substituent on isoquinoline to rotate amide bond to match PET-UNK-29afea89-2 crystal structure geometry.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Thu, 08 Apr 2021 15:46:49 +0000