Submission Details

EDJ-MED-c4e42105
Molecule(s):
CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CN(CC(=O)NC4COC4)C(=O)c4ccc(Cl)cc43)c2c1

EDJ-MED-c4e42105-1

CS(=O)(=O)Nc1ccc2cncc(NC(=O)C3CN(CC(=O)NC4COC4)C(=O)c4ccc(Cl)cc43)c2c1

CC(C)(C)NC(=O)CN1CC(C(=O)Nc2cncc3ccc(NS(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

EDJ-MED-c4e42105-2

CC(C)(C)NC(=O)CN1CC(C(=O)Nc2cncc3ccc(NS(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

CNC(=O)C(C)(C)N1CC(C(=O)Nc2cncc3ccc(NS(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

EDJ-MED-c4e42105-3

CNC(=O)C(C)(C)N1CC(C(=O)Nc2cncc3ccc(NS(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

CNC(=O)C1(N2CC(C(=O)Nc3cncc4ccc(NS(C)(=O)=O)cc34)c3cc(Cl)ccc3C2=O)CC1

EDJ-MED-c4e42105-4

CNC(=O)C1(N2CC(C(=O)Nc3cncc4ccc(NS(C)(=O)=O)cc34)c3cc(Cl)ccc3C2=O)CC1

Design Rationale:

Addressing possible permeability and metabolism issues of MAT-POS-2e8b2191-11.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Wed, 08 Sep 2021 11:21:15 +0000