Submission Details

EDJ-MED-c3ea9889
Molecule(s):
CCc1ccc2c(NC(=O)C3(C)CN(CC(=O)NC)S(=O)(=O)c4ccc(Cl)cc43)cncc2c1

EDJ-MED-c3ea9889-1

CCc1ccc2c(NC(=O)C3(C)CN(CC(=O)NC)S(=O)(=O)c4ccc(Cl)cc43)cncc2c1

3-aminopyridine-like Check Availability on Manifold View
CNC(=O)CN1CC(C)(C(=O)Nc2cncc3cc(Cl)ccc23)c2cc(Cl)ccc2S1(=O)=O

EDJ-MED-c3ea9889-2

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3cc(Cl)ccc23)c2cc(Cl)ccc2S1(=O)=O

3-aminopyridine-like Assayed Check Availability on Manifold View
CNC(=O)CN1CC(C)(C(=O)Nc2cncc3cc(S(C)(=O)=O)ccc23)c2cc(Cl)ccc2S1(=O)=O

EDJ-MED-c3ea9889-3

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3cc(S(C)(=O)=O)ccc23)c2cc(Cl)ccc2S1(=O)=O

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3cccc(Cl)c23)c2cc(Cl)ccc2S1(=O)=O

EDJ-MED-c3ea9889-4

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3cccc(Cl)c23)c2cc(Cl)ccc2S1(=O)=O

3-aminopyridine-like Assayed Check Availability on Manifold View
CS(=O)(=O)c1ccc2c(NC(=O)C34CC(C3)Oc3ccc(Cl)cc34)cncc2c1

EDJ-MED-c3ea9889-5

CS(=O)(=O)c1ccc2c(NC(=O)C34CC(C3)Oc3ccc(Cl)cc34)cncc2c1

O=C(Nc1cncc2cc(F)ccc12)C12CC(C1)Oc1ccc(Cl)cc12

EDJ-MED-c3ea9889-6

O=C(Nc1cncc2cc(F)ccc12)C12CC(C1)Oc1ccc(Cl)cc12

O=C(Nc1cncc2cc(Cl)ccc12)C12CC(C1)Oc1ccc(Cl)cc12

EDJ-MED-c3ea9889-7

O=C(Nc1cncc2cc(Cl)ccc12)C12CC(C1)Oc1ccc(Cl)cc12

O=C(Nc1cncc2cccc(Cl)c12)C12CC(C1)Oc1ccc(Cl)cc12

EDJ-MED-c3ea9889-8

O=C(Nc1cncc2cccc(Cl)c12)C12CC(C1)Oc1ccc(Cl)cc12

Design Rationale:

Metabolism reducing P2 make IQ metabolism reducing substituents

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Fri, 17 Sep 2021 16:26:39 +0000