Submission Details

EDJ-MED-9e38fd34
Molecule(s):
CC1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2ccc(Cl)cc21

EDJ-MED-9e38fd34-1

CC1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
C[C@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2ccc(Cl)cc21

EDJ-MED-9e38fd34-2

C[C@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
C[C@@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2ccc(Cl)cc21

EDJ-MED-9e38fd34-3

C[C@@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2cc(Cl)c(Cl)cc21

EDJ-MED-9e38fd34-4

CC1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
C[C@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2cc(Cl)c(Cl)cc21

EDJ-MED-9e38fd34-5

C[C@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
C[C@@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2cc(Cl)c(Cl)cc21

EDJ-MED-9e38fd34-6

C[C@@]1(C(=O)Nc2cncc3ccccc23)C(=O)Nc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

hybrids of EDJ-MED-12c115cc-1 and MAT-POS-8d5af1ef-1 with additional Me to remove risk of aromatisation

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Tue, 12 Jan 2021 11:27:04 +0000