Submission Details

EDJ-MED-7587a9ee
Molecule(s):
CN1C(=O)N(c2cncc3ccccc23)C(=O)C12CN(S(C)(=O)=O)Cc1ccc(Cl)cc12

EDJ-MED-7587a9ee-1

CN1C(=O)N(c2cncc3ccccc23)C(=O)C12CN(S(C)(=O)=O)Cc1ccc(Cl)cc12

3-aminopyridine-like Ordered Check Availability on Manifold View
CS(=O)(=O)N1Cc2ccc(Cl)cc2C2(CCCN(c3cncc4ccccc34)C2=O)C1

EDJ-MED-7587a9ee-2

CS(=O)(=O)N1Cc2ccc(Cl)cc2C2(CCCN(c3cncc4ccccc34)C2=O)C1

3-aminopyridine-like Check Availability on Manifold View
CS(=O)(=O)N1Cc2ccc(Cl)cc2C2(CCN(c3cncc4ccccc34)C2=O)C1

EDJ-MED-7587a9ee-3

CS(=O)(=O)N1Cc2ccc(Cl)cc2C2(CCN(c3cncc4ccccc34)C2=O)C1

3-aminopyridine-like Ordered Check Availability on Manifold View
CS(=O)(=O)N1Cc2ccc(Cl)cc2C2(C1)OCCN(c1cncc3ccccc13)C2=O

EDJ-MED-7587a9ee-4

CS(=O)(=O)N1Cc2ccc(Cl)cc2C2(C1)OCCN(c1cncc3ccccc13)C2=O

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Combination of MAT-POS-dd3ad2b5-4 and spirocyclic compounds in attempt to increase potency of spirocyclic compounds while blocking amide cleavage.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Thu, 08 Apr 2021 15:26:31 +0000