Submission Details

EDJ-MED-2f867453
Molecule(s):
CC1(C(=O)Nc2cncc3ccccc23)CNc2ccc(Cl)cc21

EDJ-MED-2f867453-1

CC1(C(=O)Nc2cncc3ccccc23)CNc2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CNc2cc(Cl)c(Cl)cc21

EDJ-MED-2f867453-2

CC1(C(=O)Nc2cncc3ccccc23)CNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

N analogue of potent EDJ-MED-12c115cc-1quaternary Me added to avoid indole aromatisation, di Cl for increased potency and reduced metabolism

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Mon, 11 Jan 2021 13:37:37 +0000