Submission Details

EDJ-MED-239d8ca5
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1cncc2cnn(C3CC3)c12

EDJ-MED-239d8ca5-1

O=C(Cc1cccc(Cl)c1)Nc1cncc2cnn(C3CC3)c12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1cncc2cnn(C3COC3)c12

EDJ-MED-239d8ca5-2

O=C(Cc1cccc(Cl)c1)Nc1cncc2cnn(C3COC3)c12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Slightly larger N-R groups to increase amide out of plane rotation to increase potency while controlling logP.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Thu, 19 Aug 2021 17:49:11 +0000