Submission Details
Molecule(s):
DRR-IMP-dff87f5e-1
Duplicate of:
KAY-MCD-d0fe5261-1
O=C(CCl)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1
DRR-IMP-dff87f5e-2
Duplicate of:
MAK-UNK-7c9d1431-3
O=C(CCl)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1
DRR-IMP-dff87f5e-3
Duplicate of:
AAR-POS-d2a4d1df-44
O=C(CCl)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1
O=C(CCl)N1CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1
DRR-IMP-dff87f5e-5
Duplicate of:
AAR-POS-d2a4d1df-34
O=C(CCl)N1CCN(S(=O)(=O)c2ccccc2F)CC1
O=C(CCl)N1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
O=C(CCl)N1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1
O=C(CCl)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1
N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)CCl)CC2)cc1
Design Rationale:
We have studied, in collaboration with Ben Perry at the DNDi, the SAR available on the piperazine-chloroacetamide series. My current Masters student has synthesized these 9 molecules.
Other Notes:
Previous Masters student also worked on this series. Synthesis is very straightforward and reliable.