Submission Details
Molecule(s):
O=C(CCl)N1CCN(S(=O)(=O)c2ccsc2)[C@H](C(=O)N2CCN(c3ccccc3)CC2)C1
Design Rationale:
The design of this compound comes from a very potent fragment MAT-POS-ee51dedd2. Crystallography analysis would suggest that building a group from one of the piperazine carbons may provide a bridge to the pocket where several of the 3-aminopyridine like fragments are bound (fragment linking).