Submission Details

BEN-DND-02317c5c
Molecule(s):
O=C(Cc1ccc(Cl)c(Cl)c1)Nc1cnc2ccccn12

BEN-DND-02317c5c-1

O=C(Cc1ccc(Cl)c(Cl)c1)Nc1cnc2ccccn12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnc2ccccn12)[C@@H]1CCOc2cc(Cl)c(Cl)cc21

BEN-DND-02317c5c-2

O=C(Nc1cnc2ccccn12)[C@@H]1CCOc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnc2ccccn12)[C@@H]1CCOc2ccc(Cl)cc21

BEN-DND-02317c5c-3

O=C(Nc1cnc2ccccn12)[C@@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnc2ccccn12)[C@@H]1CCOc2cc(F)c(Cl)cc21

BEN-DND-02317c5c-4

O=C(Nc1cnc2ccccn12)[C@@H]1CCOc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnc2ccccn12)[C@@H]1CCNc2cc(Cl)c(Cl)cc21

BEN-DND-02317c5c-5

O=C(Nc1cnc2ccccn12)[C@@H]1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cnc2ccccn12)[C@@H]1CCNc2ccc(Cl)cc21

BEN-DND-02317c5c-6

O=C(Nc1cnc2ccccn12)[C@@H]1CCNc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnc2ccccn12)[C@@H]1CCNc2cc(F)c(Cl)cc21

BEN-DND-02317c5c-7

O=C(Nc1cnc2ccccn12)[C@@H]1CCNc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1nnc2ccccn12

BEN-DND-02317c5c-8
Duplicate of:
PET-UNK-e44ffd04-1

O=C(Cc1cccc(Cl)c1)Nc1nnc2ccccn12

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1ncc2ccccn12

BEN-DND-02317c5c-9
Duplicate of:
EDJ-MED-50fe53e8-4

O=C(Cc1cccc(Cl)c1)Nc1ncc2ccccn12

Duplicate 3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1ccc(Cl)c(Cl)c1)Nc1cnn2ccccc12

BEN-DND-02317c5c-10

O=C(Cc1ccc(Cl)c(Cl)c1)Nc1cnn2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Cn1cnc2ccccc21)Nc1cccc(Cl)c1

BEN-DND-02317c5c-11
Duplicate of:
BEN-DND-61647d40-13

O=C(Cn1cnc2ccccc21)Nc1cccc(Cl)c1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cn1nnc2ccccc21)Nc1cccc(Cl)c1

BEN-DND-02317c5c-12
Duplicate of:
BEN-DND-61647d40-12

O=C(Cn1nnc2ccccc21)Nc1cccc(Cl)c1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1ccc(Cl)c(Cl)c1)Nc1cncn1-c1ccccc1

BEN-DND-02317c5c-13

O=C(Cc1ccc(Cl)c(Cl)c1)Nc1cncn1-c1ccccc1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Building off the mid-uM potency of PET-UNK-8df914d1-2 as an isoquinoline replacement

Inspired By:
Discussion:

Contributor: Benjamin Perry, DNDi - Wed, 10 Mar 2021 08:29:50 +0000