Submission Details

ADA-UCB-6c2cb422
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1cncc2ccccc12

ADA-UCB-6c2cb422-1

O=C(Cc1cccc(Cl)c1)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)[C@@H]1CCc2ccc(Cl)cc21

ADA-UCB-6c2cb422-2

Cc1ccncc1NC(=O)[C@@H]1CCc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1CC(=O)Nc1cccc2c1CNCC2

ADA-UCB-6c2cb422-3

Cc1ccncc1CC(=O)Nc1cccc2c1CNCC2

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cccc2c1CNCC2

ADA-UCB-6c2cb422-4

Cc1ccncc1NC(=O)Cc1cccc2c1CNCC2

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1-n1cc(C#N)cc(-c2cccc(Cl)c2)c1=O

ADA-UCB-6c2cb422-5

Cc1ccncc1-n1cc(C#N)cc(-c2cccc(Cl)c2)c1=O

Cc1ccncc1-c1cc(C#N)cn(-c2cccc(Cl)c2)c1=O

ADA-UCB-6c2cb422-6

Cc1ccncc1-c1cc(C#N)cn(-c2cccc(Cl)c2)c1=O

COc1ccccc1[C@@H]1CN(c2cccc(Cl)c2)C(=O)N(c2cnccc2C)C1

ADA-UCB-6c2cb422-7

COc1ccccc1[C@@H]1CN(c2cccc(Cl)c2)C(=O)N(c2cnccc2C)C1

3-aminopyridine-like Ordered Check Availability on Manifold View
COc1ccccc1OC[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ADA-UCB-6c2cb422-8

COc1ccccc1OC[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
COc1ccccc1OC[C@H](C(=O)Nc1cnccc1C)c1cccc(Cl)c1

ADA-UCB-6c2cb422-9

COc1ccccc1OC[C@H](C(=O)Nc1cnccc1C)c1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
COc1ccccc1CN[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ADA-UCB-6c2cb422-10

COc1ccccc1CN[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
COc1ccccc1CO[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ADA-UCB-6c2cb422-11

COc1ccccc1CO[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Designs submitted by the UCB med-chem team

Discussion:

Contributor: Adam Smalley, UCB - Fri, 19 Jun 2020 18:39:43 +0000